In silico transcriptome-based drug screening identifies celastrol as a multi-species therapeutic agent against aging-related sarcopenia and mitochondrial dysfunction
Collectively, these findings suggest celastrol as apharmacological mimetic of exercise-induced mitochondrial rejuvenation, offering a translatable strategy to combat age-related muscle decline.
Authors
- Fangqu Liu
- Jiaxin Liu (ORCID: https://orcid.org/0000-0001-7873-1418)
- Yanyan Li (ORCID: https://orcid.org/0000-0002-0649-9047)
- Yuxia Chen
- Yuhan Tang
- Li Chen
- Yuna Tian
- Xingzhu Yin
- Bangfu Wu
- Xiaocui Liu
- Li Mo
- Ping Yao
- Chao Gao
- Huimin Chen
- Zhaoyu Cui
- Xuer Cheng
- Yu Fei Wang
- Chanhua Liang
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Ministry of Education (KR)
- Oil Crops Research Institute (CN)
- Shenzhen Nanshan Center for Chronic Disease Control (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.01.079
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00