Super-resolution mapping reveals NAD⁺-delivering probiotic extracellular vesicles as nanotherapeutics for organelle protection and inflammation control
These findings establish NAD⁺-mediated organelle protection as a central mechanism through which probiotic EVs mitigate bacterial inflammation. By linking organelle integrity to inflammatory outcomes, our study highlights L. plantarum EVs as nanoscale therapeutic candidates for infection-driven inflammation.
Authors
- Yunkwan Kim (ORCID: https://orcid.org/0000-0003-1353-4784)
- Uidon Jeong (ORCID: https://orcid.org/0000-0003-4799-2660)
- Nae-Gyu Kang
- Sanghee Lee (ORCID: https://orcid.org/0000-0002-6574-8656)
- Doory Kim (ORCID: https://orcid.org/0000-0002-2675-106X)
- Bo Kyoung Hwang (ORCID: https://orcid.org/0009-0009-2080-2602)
- Minjae Kang
- Sangoh Choi
- Euitaek Jeong
- Seongsu Kang
- Eunyoung Moon
- Ga-eun Go
Institutions
- LG (United States) (US)
- Korea Basic Science Institute (KR)
- Hanyang University (KR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s12951-026-04090-1
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Hanyang University
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Toray Science Foundation