One-Year Real-World Outcomes of Aflibercept 8 mg in Treatment-Naïve Neovascular Age-Related Macular Degeneration: A Swiss Retina Research Network Report
The first 1-year real-world experience with afl8 in patients with nAMD revealed a robust anatomical response but only a variable and limited visual gain over 12 months due to a ceiling effect. Our findings confirm the fast and sustained macular drying reported from clinical trials, allowing for extended treatment intervals without compromising safety and efficacy.
Authors
- Christin Schild (ORCID: https://orcid.org/0000-0001-7705-1103)
- Moreno Menghini (ORCID: https://orcid.org/0000-0002-1432-2524)
- Andreas Ebneter (ORCID: https://orcid.org/0000-0001-6666-2558)
- Sandrine Zweifel (ORCID: https://orcid.org/0000-0001-7431-1774)
- Gábor Márk Somfai (ORCID: https://orcid.org/0000-0001-6329-442X)
- Gabriela Grimaldi (ORCID: https://orcid.org/0000-0003-2435-7867)
- Chiara Maria Eandi (ORCID: https://orcid.org/0000-0003-3656-1689)
- Eva Cristina de Oliveira Figueiredo (ORCID: https://orcid.org/0000-0003-2161-4135)
- Isabel B. Pfister (ORCID: https://orcid.org/0000-0001-8752-8390)
- Anne Tillmann
- Marion Rohit Munk
- Tahm Spitznagel
- Nicolò Bartolomeo (ORCID: https://orcid.org/0000-0001-9522-7176)
- Felix Gabathuler
- Aude Ambresin
- Alice M. Kitay
- Arianna Peyla
- Malaika Mihal Kurz-Levin
- Justus G. Garweg
Institutions
- Semmelweis University (HU)
- Northwestern University (US)
- Kantonsspital St. Gallen (CH)
- Triemli Hospital (CH)
- University Hospital of Bern (CH)
- Laboratory for Biomedical Neurosciences (CH)
- Berner Augenklinik am Lindenhofspital (CH)
- Ente Ospedaliero Cantonale (CH)
- University Hospital of Zurich (CH)
- Universitätsklinik für Augenheilkunde (CH)
- Fondation Asile des Aveugles (CH)
- Praxis für Humangenetik (DE)
- Immunologie-Zentrum Zürich (CH)
- Swiss Finance Institute (CH)
- University of Turin (IT)
Publication Details
- Journal
- Ophthalmology and Therapy
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1007/s40123-025-01305-w
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00