Kynurenic acid mitigates poststroke brain damage through the gut-brain neural circuit
KYNA acts through an intestinal GPR35-vagus neural pathway to influence stroke recovery, highlighting this gut-brain signalling axis as a promising therapeutic avenue.
Authors
- Yisi Liu (ORCID: https://orcid.org/0000-0002-2121-8557)
- Xiaoqi Huang (ORCID: https://orcid.org/0000-0001-8547-1060)
- Zhuang Li (ORCID: https://orcid.org/0000-0001-9740-1588)
- Siqi Yang (ORCID: https://orcid.org/0000-0002-7239-7831)
- Peibo Yuan
- Shengnan Chen
- Kaiyu Xu
- Jiaxuan Wang
- Jie Li
- Jia Yin
- Wen Zhang
- Hongwei Zhou
- Yonghui Guo
Institutions
- Nanfang Hospital (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Zhujiang Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1136/gutjnl-2025-337690
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00