A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

This mini-review describes the pathophysiology of the disrupted hypothalamic-pituitary-adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1-1Δ in dogs and ABCB11930-1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.

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Publication Details

Journal
Journal of Small Animal Practice
Published
2026-02-03
DOI
https://doi.org/10.1111/jsap.70098
Primary Topic
Veterinary Medicine and Surgery
Type
article
Field-Weighted Citation Impact
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article

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

K. L. Mealey
Journal of Small Animal Practice
Veterinary Medicine and Surgery
article

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

K. L. Mealey
article en

Abstract

This mini-review describes the pathophysiology of the disrupted hypothalamic-pituitary-adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1-1Δ in dogs and ABCB11930-1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.

Journal of Small Animal Practice
Washington State University (US)
Good health and well-being
Openalex Percentile: Top 67%
Veterinary Medicine and Surgery
DOIOpen Access PDFOpenAlex
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A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency — K. L. Mealey · Journal of Small Animal Practice (2026) | TGRS Research Map | TGRS