Single‐Cell <scp>RNA</scp> Sequencing and Bulk <scp>RNA</scp> Sequencing Revealed the Interplay Between Intratumoral Heterogeneity and the Tumor Microenvironment in Breast Cancer
Our comprehensive analysis of cell-cell communication networks among epithelial cells, fibroblasts, macrophages, and lymphocytes across BC subtypes focuses on ligand-receptor interactions. This study revealed that certain molecules within these networks exhibit significant prognostic value and therapeutic promise.
Authors
- Mingyu Gong
- Xiu‐An Yang
- Fengchun Lv
- Xiaoyu Zhang
- Yunlong Zhao
- Yingying Wang
- Xiaomin Yu
Institutions
- Chengde Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cam4.71600
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province
- Chengde Medical University
- Horizon 2020 Framework Programme