Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance

The ANT encoded by eanT-1 in Exiguobacterium sp. PL221A mediates resistance to kanamycin, which can be counteracted by the alkaloid bicuculline through inhibition of its catalytic activity.

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Publication Details

Journal
BMC Microbiology
Published
2026-02-03
DOI
https://doi.org/10.1186/s12866-026-04746-w
Primary Topic
Carbohydrate Chemistry and Synthesis
Type
article
Field-Weighted Citation Impact
0.00
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article

Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance

Peitong Yang, Gongli Zong, Minghui Yu, Yongan Wang et al.
BMC Microbiology
Carbohydrate Chemistry and Synthesis
article

Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance

Peitong Yang, Gongli Zong, Minghui Yu, Yongan Wang, Zhihui Meng, Mingzhen Zhang, Xingyu Cui, Jiahui Wang, Ziqian Yu
article en

Abstract

The ANT encoded by eanT-1 in Exiguobacterium sp. PL221A mediates resistance to kanamycin, which can be counteracted by the alkaloid bicuculline through inhibition of its catalytic activity.

BMC MicrobiologyVol. 26(1)
Shandong First Medical University (CN)
Openalex Percentile: Top 67%
Carbohydrate Chemistry and Synthesis
DOIOpen Access PDFOpenAlex
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Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance — Peitong Yang, Gongli Zong, et al. · BMC Microbiology (2026) | TGRS Research Map | TGRS