Microbial lung-to-blood translocation associates with systemic inflammation in severe pneumonia: evidence from paired plasma and lower respiratory tract metagenomics
Microbial lung-to-blood translocation is a measurable biological process associated with systemic inflammatory heterogeneity in severe pneumonia. This pathway may represent a novel mechanistic target for precision therapeutic strategies aimed at mitigating immune dysregulation.
Authors
- Nameer Al‐Yousif (ORCID: https://orcid.org/0000-0002-2657-2360)
- Sivan Bercovici (ORCID: https://orcid.org/0000-0002-4310-4868)
- Panayiotis V. Benos (ORCID: https://orcid.org/0000-0003-3172-3132)
- William Bain (ORCID: https://orcid.org/0000-0001-8506-0552)
- Noel Britton (ORCID: https://orcid.org/0000-0001-9420-9718)
- Brett Kaufman (ORCID: https://orcid.org/0000-0001-9670-9054)
- Kevin Redding (ORCID: https://orcid.org/0000-0003-2300-4613)
- Georgios D. Kitsios (ORCID: https://orcid.org/0000-0002-1018-948X)
- Bryan J. McVerry (ORCID: https://orcid.org/0000-0002-1175-4874)
- Barbara A. Methé (ORCID: https://orcid.org/0000-0001-8711-1448)
- Haopu Yang (ORCID: https://orcid.org/0000-0001-6858-1778)
- Tim Blauwkamp
- Shulin Qin
- Matthew K. Hensley
- Vi D.-B. Nguyen
- Xiaohong Wang
- Adam Fitch
- Libing Yang
- Asim A. Ahmed
- Alison Morris
Institutions
- University of Maryland, Baltimore (US)
- University of Pittsburgh (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Johnson University (US)
- University of Florida (US)
- Lung Institute (US)
- Olive View-UCLA Medical Center (US)
- VA Pittsburgh Healthcare System (US)
- University of Pittsburgh Medical Center (US)
- Fresenius Kabi (Czechia) (CZ)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s40635-026-00862-z
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pittsburgh
- National Institutes of Health
- Medical Center, University of Pittsburgh