Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4
This longitudinal epigenome-wide study identified novel CpG sites associated with blood pressure and persistent HTN. We observed differential DNA methylation trajectories over time linked to HTN, SBP, and DBP, with several changes correlating with gene expression, suggesting functional relevance. These findings underscore the dynamic role of DNA methylation in blood pressure regulation and provide new insights into epigenetic mechanisms of HTN.
Authors
- Aiman Farzeen
- Angelina Shin Yee Jong
- Liye Lai
- Elisabeth Thiering
- Barbara Thorand
- Christian Gieger
- Annette Peters
- Juliane Winkelmann
- Melanie Waldenberger
- Thomas Delerue
- Margit Heier
Institutions
- Zimmer Biomet (Netherlands) (NL)
- Munich University of Applied Sciences (DE)
- University Hospital Augsburg (DE)
- Helmholtz Zentrum München (DE)
- Southern University of Science and Technology (CN)
- Munich Cluster for Systems Neurology (DE)
- University Children's Hospital Tübingen (DE)
- German Centre for Cardiovascular Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s12916-026-04672-8
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00