Prediction of Mutations and Outcome in Gastrointestinal Stromal Tumors with Deep Learning: A Multicenter, Multinational Study
DL applied to WSIs enables prediction of molecular alterations, treatment sensitivity, and RFS in GIST, performing comparably to established risk scores across international cohorts, providing a baseline for future multimodal predictors.
Authors
- Hester H. van Boven
- Hans Gelderblom
- I. Soubeyran
- Lucile Vanhersecke (ORCID: https://orcid.org/0000-0001-7733-7806)
- Emilio Medina-Ceballos (ORCID: https://orcid.org/0009-0003-6022-0910)
- Isidro Morales Machado
- Alexandra Meurgey (ORCID: https://orcid.org/0009-0003-8568-8640)
- Marco Gustav (ORCID: https://orcid.org/0009-0009-3598-5720)
- F. Le Loarer
- Suk Wai Lam (ORCID: https://orcid.org/0000-0001-9782-5938)
- Julien Bollard (ORCID: https://orcid.org/0000-0002-9378-5665)
- Hidekazu Hirano (ORCID: https://orcid.org/0000-0003-1343-1419)
- Eva Wardelmann (ORCID: https://orcid.org/0000-0001-6788-4910)
- Amandine Crombé (ORCID: https://orcid.org/0000-0003-0098-6482)
- Yasushi Yatabe
- Carolina Agra
- P. Sobczuk
- JM Coindre
- Jens Jakob (ORCID: https://orcid.org/0000-0002-8499-7172)
- Zunamys I. Carrero (ORCID: https://orcid.org/0000-0001-8501-1566)
- Jakob Nikolas Kather (ORCID: https://orcid.org/0000-0002-3730-5348)
- Raul Perret (ORCID: https://orcid.org/0000-0003-2698-0249)
- Neeltje Steeghs
- M. Jean-Denis
- Laura Blouin
- O. Bouche
- Alba Hernández Gallego
- Judith V.M.G. Bovée (ORCID: https://orcid.org/0000-0003-1155-0481)
- Samuel Navarro (ORCID: https://orcid.org/0000-0001-5016-5653)
- Artem Voloshin
- A. Lecesne
- Cristina Cotarelo
- J Emile
- Van-Linh Le
- Piotr Rutkowski (ORCID: https://orcid.org/0000-0002-8920-5429)
- Joris M van Sabben
- Arianna Bonetti
- Anna Szumera-Ciećkiewicz
- Míriam Cuatrecasas
- Sandra Lopez-Prades
- Carine Ngo
- Malgorzata Lenarcik
- Francisco Giner
- Peter Hohenberger
- Alessandro Gronchi
- Antoine Italiano
- Nathalie Lassau
- Gemma Civantos Jubera
- Toshirou Nishida
- Silvia Bague
- Gustavo Tapia
- Fabian Wolf
- Emmanuel Khalifa
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Leeds (GB)
- Institut national de recherche en sciences et technologies du numérique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Universitat de València (ES)
- University of Milan (IT)
- Utrecht University (NL)
- Heidelberg University (DE)
- Université Paris-Saclay (FR)
- Leiden University Medical Center (NL)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Institut Gustave Roussy (FR)
- University Hospital Heidelberg (DE)
- The Netherlands Cancer Institute (NL)
- Hospital General Universitario Gregorio Marañón (ES)
- University Medical Center Utrecht (NL)
- Hospital Universitari i Politècnic La Fe (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- Fundación Instituto Valenciano de Oncología (ES)
- University Hospital Münster (DE)
- Centre Léon Bérard (FR)
- Centre Hospitalier Universitaire de Reims (FR)
- Oncode Institute (NL)
- National Center for Tumor Diseases (DE)
- Hospital Quirónsalud Barcelona (ES)
- Hospital Clínic de Barcelona (ES)
- National Institute of Oncology (HU)
- Centre Inria de l'université de Bordeaux (FR)
- Japan Community Healthcare Organization (JP)
- Hôpital Ambroise-Paré (FR)
- Institut Bergonié (FR)
- Postgraduate School of Molecular Medicine (PL)
- National Cancer Center Hospital East (JP)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Tokyo National Hospital (JP)
- University Medical Centre Mannheim (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- INCLIVA Health Research Institute (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University Hospital Carl Gustav Carus (DE)
- Medical Research Network (US)
- Institut de Mathématiques de Bordeaux (FR)
- Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (FR)
- Universitat de Barcelona (ES)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-03
- DOI
- https://doi.org/10.64898/2026.02.02.26345350
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Technische Universität Dresden
- Gauss Centre for Supercomputing