Integrated Proteomics and Metabolomics Reveal Multifaceted Mechanisms of Colistin Resistance in Acinetobacter baumannii
Colistin resistance in <i>A. baumannii</i> appears to involve a multifaceted strategy integrating lipid A modification, cell membrane remodeling, and metabolic reprogramming. This study provides a high-resolution molecular blueprint of colistin resistant <i>A. baumannii</i> and generates testable hypotheses to inform future diagnostic and therapeutic strategies against resistant infections.
Authors
- Nadeem Ullah (ORCID: https://orcid.org/0000-0001-6089-8906)
- Shuquan Wei (ORCID: https://orcid.org/0000-0003-4044-2244)
- Zhike Liang
- Xiao Yang
- Yujun Li
- Qizhi Wang
- Ling Hao
- Zhuxiang Zhao
Institutions
- Guangzhou First People's Hospital (CN)
- Umeå University (SE)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/idr.s573066
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Bureau
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province