Randomized Trial Links Time of Day to Immunotherapy Success

Morning administration of checkpoint inhibitors significantly extended survival in patients with advanced non-small cell lung cancer, in the first randomized trial of immunotherapy timing. The results provide prospective support for aligning treatment with circadian biology as a simple way to improve cancer outcomes.

Publication Details

Journal
Cancer Discovery
Published
2026-02-02
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0010
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
0.00
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article

Randomized Trial Links Time of Day to Immunotherapy Success

Cancer Discovery
Circadian rhythm and melatonin
article

Randomized Trial Links Time of Day to Immunotherapy Success

article en

Abstract

Morning administration of checkpoint inhibitors significantly extended survival in patients with advanced non-small cell lung cancer, in the first randomized trial of immunotherapy timing. The results provide prospective support for aligning treatment with circadian biology as a simple way to improve cancer outcomes.

Cancer DiscoveryVol. 16(3)
Good health and well-being
Openalex Percentile: Top 64%
Circadian rhythm and melatonin
DOISourceOpenAlex
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