A case of sarcomatoid carcinoma of the lung treated with a new radiopharmaceutical 225Ac-DOTA-IBA

DOTA-IBA is a novel bone-targeting precursor for metastatic bone disease. It was radiolabeled with 225Ac to generate the alpha-emitting therapeutic agent 225Ac-DOTA-IBA. In this report, a 70-year-old man with pulmonary sarcomatoid carcinoma and extensive skeletal metastases was treated upfront with 2 cycles of 225Ac-DOTA-IBA. The patient showed excellent symptomatic and radiological response. In addition, no adverse effects were observed in the patient.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2025-11-26
DOI
https://doi.org/10.1097/rlu.0000000000006234
Primary Topic
Metastasis and carcinoma case studies
Type
article
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article

A case of sarcomatoid carcinoma of the lung treated with a new radiopharmaceutical 225Ac-DOTA-IBA

W Wang, Chunmei Tian, Yueqi Zhao, Yue Chen et al.
Clinical Nuclear Medicine
Metastasis and carcinoma case studies
article

A case of sarcomatoid carcinoma of the lung treated with a new radiopharmaceutical 225Ac-DOTA-IBA

W Wang, Chunmei Tian, Yueqi Zhao, Yue Chen, Xiangting Liu
article en

Abstract

DOTA-IBA is a novel bone-targeting precursor for metastatic bone disease. It was radiolabeled with 225Ac to generate the alpha-emitting therapeutic agent 225Ac-DOTA-IBA. In this report, a 70-year-old man with pulmonary sarcomatoid carcinoma and extensive skeletal metastases was treated upfront with 2 cycles of 225Ac-DOTA-IBA. The patient showed excellent symptomatic and radiological response. In addition, no adverse effects were observed in the patient.

Clinical Nuclear MedicineVol. 51(3)
Southwest Medical University (CN), Affiliated Hospital of Southwest Medical University (CN), Theranostics (New Zealand) (NZ), Molecular Theranostics (United States) (US)
Good health and well-being
Openalex Percentile: Top 25%
Metastasis and carcinoma case studies
DOISourceOpenAlex
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