Metaheuristic-driven dual-layer model for classifying Alzheimer's disease stages

To improve transparency and clinical relevance, explainable artificial intelligence (XAI) techniques were incorporated to interpret model predictions and highlight feature importance. The results provide meaningful insights into neuroimaging biomarkers associated with AD progression and support the development of more interpretable and trustworthy diagnostic systems. Overall, the proposed framework contributes to improved data-driven decision support and offers a promising direction for future Alzheimer's disease diagnosis and staging research.

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Publication Details

Journal
Frontiers in Computational Neuroscience
Published
2026-02-03
DOI
https://doi.org/10.3389/fncom.2026.1731812
Citations
1
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
33.12

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article

Metaheuristic-driven dual-layer model for classifying Alzheimer's disease stages

Tamara Živković, Miloš Antonijević, Svetlana Andjelić, Nebojsa Bacanin et al.
1 citations
Frontiers in Computational Neuroscience
Dementia and Cognitive Impairment Research
33.12
article

Metaheuristic-driven dual-layer model for classifying Alzheimer's disease stages

Tamara Živković, Miloš Antonijević, Svetlana Andjelić, Nebojsa Bacanin, Dejan Bulaja, Marija Markovic Blagojevic, Miodrag Zivkovic, Luka Anicin
article en
1 citations

Abstract

To improve transparency and clinical relevance, explainable artificial intelligence (XAI) techniques were incorporated to interpret model predictions and highlight feature importance. The results provide meaningful insights into neuroimaging biomarkers associated with AD progression and support the development of more interpretable and trustworthy diagnostic systems. Overall, the proposed framework contributes to improved data-driven decision support and offers a promising direction for future Alzheimer's disease diagnosis and staging research.

Frontiers in Computational NeuroscienceVol. 20
Singidunum University (RS), Saveetha University (IN)
Science Fund of the Republic of Serbia
Reduced inequalities
Openalex Percentile: Top 1%
Dementia and Cognitive Impairment Research
33.12
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