Metaheuristic-driven dual-layer model for classifying Alzheimer's disease stages
To improve transparency and clinical relevance, explainable artificial intelligence (XAI) techniques were incorporated to interpret model predictions and highlight feature importance. The results provide meaningful insights into neuroimaging biomarkers associated with AD progression and support the development of more interpretable and trustworthy diagnostic systems. Overall, the proposed framework contributes to improved data-driven decision support and offers a promising direction for future Alzheimer's disease diagnosis and staging research.
Authors
- Tamara Živković (ORCID: https://orcid.org/0000-0003-2969-1709)
- Miloš Antonijević (ORCID: https://orcid.org/0000-0002-5511-2531)
- Svetlana Andjelić
- Nebojsa Bacanin
- Dejan Bulaja
- Marija Markovic Blagojevic
- Miodrag Zivkovic
- Luka Anicin
Institutions
- Singidunum University (RS)
- Saveetha University (IN)
Publication Details
- Journal
- Frontiers in Computational Neuroscience
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fncom.2026.1731812
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 33.12
Funders
- Science Fund of the Republic of Serbia