Dopamine’s secret agent: serotonin
Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent-instituting a high-pass filter on striatal 'direct pathway' transmission-and does not require dopamine receptors. Rather, dopamine upregulates serotonin, activating presynaptic 5HT<sub>1B</sub> receptors to exert its effects.
Authors
- Andrew Miller‐Hansen (ORCID: https://orcid.org/0000-0003-2621-0930)
- Talia N. Lerner (ORCID: https://orcid.org/0000-0002-3875-0654)
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Trends in Neurosciences
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.tins.2025.12.008
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 23.21