The rise of 3D spheroids in radiobiology for assessing tumour radioresistance
This study introduces a robust 3D preclinical platform for radiobiological assessment of particle therapy. CIRT consistently overcame intrinsic and microenvironment-mediated resistance, outperforming photons and protons in suppressing viability, invasion and spheroid integrity, thus reinforcing the translational relevance of 3D models and the therapeutic promise of carbon ion therapy for resistant malignancies.
Authors
- Angelica Facoetti (ORCID: https://orcid.org/0000-0001-8215-9258)
- Paola Tabarelli de Fatis (ORCID: https://orcid.org/0000-0002-5721-9295)
- Giuseppe Magro (ORCID: https://orcid.org/0000-0001-7140-8642)
- Lorenzo Manti (ORCID: https://orcid.org/0000-0003-0168-5040)
- Maria Grazia Bottone (ORCID: https://orcid.org/0000-0003-4570-8785)
- Sara Lillo (ORCID: https://orcid.org/0000-0001-7300-1168)
- Niloufar Matoor
- Alessio Mereghetti
- Amelia Barcellini
- Alexandra Charalampopoulou
- Giorgio Butella
- Fabrizio De Luca
- Giovanni Battista Ivaldi
Institutions
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- National Center for Oncological Hadrontherapy (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Acta Oncologica
- Published
- 2026-02-03
- DOI
- https://doi.org/10.2340/1651-226x.2026.45079
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00