A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

BDMP exhibited sustained antimicrobial and anti-inflammatory activity and attenuated bone loss in a beagle periodontitis model when used alongside standard SI therapy. These findings support BDMP as a promising adjunctive therapeutic candidate for managing periodontal inflammation and biofilm-associated disease, although further studies are needed to confirm long-term safety and to define its mechanistic contributions to periodontal tissue preservation.

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Publication Details

Journal
Journal of Periodontal Research
Published
2026-02-03
DOI
https://doi.org/10.1111/jre.70079
Primary Topic
Antimicrobial Peptides and Activities
Type
article
Field-Weighted Citation Impact
0.00
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article

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Beom Soo Jo, Sanghui Seok, Ji‐Young Lee, Yang Jo Seol et al.
Journal of Periodontal Research
Antimicrobial Peptides and Activities
article

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Beom Soo Jo, Sanghui Seok, Ji‐Young Lee, Yang Jo Seol, Shin‐Young Park, J. H. Lee, Dongjin Lee, Young Dan Cho, Yu‐Bin Kim, Yoon Jeong Park
article en

Abstract

BDMP exhibited sustained antimicrobial and anti-inflammatory activity and attenuated bone loss in a beagle periodontitis model when used alongside standard SI therapy. These findings support BDMP as a promising adjunctive therapeutic candidate for managing periodontal inflammation and biofilm-associated disease, although further studies are needed to confirm long-term safety and to define its mechanistic contributions to periodontal tissue preservation.

Journal of Periodontal Research
Goethe University Frankfurt (DE), Seoul National University (KR), Seoul National University of Education (KR), Chungbuk National University (KR), New Generation University College (ET), Intelligent Energy (United Kingdom) (GB), Seoul National University Dental Hospital (KR)
Openalex Percentile: Top 67%
Antimicrobial Peptides and Activities
DOIOpen Access PDFOpenAlex
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