PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells
These findings demonstrate that PFAS-induced pro-inflammatory cytokines is mediated, at least in part, through PPARγ signaling, and that pharmacological activation of PPARγ signaling can attenuate PFAS-triggered pro-inflammatory cytokine responses in lung epithelial cells.
Authors
- Khursheed Ul Islam
- Virender K. Rehan (ORCID: https://orcid.org/0000-0002-8948-8967)
- Md Imam Faizan
- Sadiya Bi Shaikh
- Irfan Rahman
Institutions
- University of Rochester Medical Center (US)
- Harbor–UCLA Medical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fphar.2026.1779345
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00