Single-cell sequencing reveals cellular composition and tumor microenvironment alterations across risk stratification in cutaneous squamous cell carcinoma
This study establishes iCAFs and γδT cell loss as central drivers of cSCC aggressiveness and nominates CXCL8/TGFβ/IGFBP7 dysregulation as a biomarker framework for risk stratification. Collectively, these findings unveil actionable therapeutic targets and provide a molecular basis for personalizing management strategies, particularly for identifying and treating very high-risk cSCC patients who may benefit from intensified surgical approaches, adjuvant therapies, or novel targeted interventions.
Authors
- Suling Xu
- Yong Cui (ORCID: https://orcid.org/0000-0002-3658-1770)
- Jingkai Xu (ORCID: https://orcid.org/0000-0002-3640-1602)
- Xinzhu Zhou (ORCID: https://orcid.org/0000-0002-6432-0033)
- Xiaoyi Huang
- Lei Li (ORCID: https://orcid.org/0000-0002-1867-106X)
- Xianbo Zuo
- Q Xia
- Zhou Zhuang
- Tingting Jiang
- Yue Yang
Institutions
- Ningbo University (CN)
- Anhui Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Southeast University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1097/js9.0000000000003761
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81