The Prognostic Significance of KRAS, NRAS, and BRAF Mutations in Colorectal Cancer: A Systematic Review and Meta-Analysis
This meta-analysis shows that KRAS, NRAS, and BRAF mutations are important for adverse prognostic markers in colorectal cancer, linked to reduced overall survival. Routine molecular testing for these mutations is vital to enable personalized treatment, improve patient stratification, and enhance clinical outcomes in colorectal cancer management.
Authors
- Ewarld Marshall
- Odinaka E. Mgbeke
- Aminatulahi Egbeyemi
- Abraham Agaya Obadiah
- Mathew Oyelami
Institutions
- St. George's University (GD)
Publication Details
- Journal
- Clinical Medicine Insights Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1177/11795549261417367
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00