Lipid nanoparticle-delivered ornithine transcarbamylase mRNA alleviates liver fibrosis in preclinical models
Collectively, our study provides the first direct preclinical evidence supporting OTC mRNA therapeutics for treating liver fibrosis and establishes proof-of-concept for mRNA therapy as a novel strategy to reverse liver fibrosis.
Authors
- Yuenan Chen
- Jiaping Ni (ORCID: https://orcid.org/0000-0001-8179-3740)
- Xianyu Shao
- Xu Lu (ORCID: https://orcid.org/0000-0003-4892-5240)
- Jingtong Li
- Weijun Zhao
- Yijun Yang (ORCID: https://orcid.org/0000-0002-9855-9616)
- Yumeng Shen
- Dongqing Zhai
- Ang Lin
- Kailin Fan
Institutions
- China Pharmaceutical University (CN)
- Center for Innovative Public Health Research (US)
Publication Details
- Journal
- Hepatology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1097/hep.0000000000001708
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00