LncRNA GAS6-AS2 regulates vascular smooth muscle cell senescence through the miR-138-5p/AKT1 axis and serves as a diagnostic and prognostic marker for atherosclerosis

GAS6-AS2 is a potential diagnostic and prognostic biomarker for AS. It regulates ox-LDL-induced VSMC senescence and inflammatory response through the sponging of miR-138-5p to upregulate AKT1, providing a novel molecular target for AS treatment.

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Publication Details

Journal
Hereditas
Published
2026-02-03
DOI
https://doi.org/10.1186/s41065-026-00650-5
Primary Topic
Phagocytosis and Immune Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

LncRNA GAS6-AS2 regulates vascular smooth muscle cell senescence through the miR-138-5p/AKT1 axis and serves as a diagnostic and prognostic marker for atherosclerosis

Zhaochuan Luo, Wei Dong, Huan Pu, Zhencheng Li et al.
Hereditas
Phagocytosis and Immune Regulation
article

LncRNA GAS6-AS2 regulates vascular smooth muscle cell senescence through the miR-138-5p/AKT1 axis and serves as a diagnostic and prognostic marker for atherosclerosis

Zhaochuan Luo, Wei Dong, Huan Pu, Zhencheng Li, Yun Qiu, Kai Xie, Xiaowen Lai, Ying E. Zhang
article en

Abstract

GAS6-AS2 is a potential diagnostic and prognostic biomarker for AS. It regulates ox-LDL-induced VSMC senescence and inflammatory response through the sponging of miR-138-5p to upregulate AKT1, providing a novel molecular target for AS treatment.

HereditasVol. 163(1)
Hebei Medical University (CN), Third Hospital of Hebei Medical University (CN), Fourth People's Hospital of Sichuan Province (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Deyang Stomatological Hospital (CN), First Hospital of Shijiazhuang (CN), Affiliated Hospital of Shaanxi University of Chinese Medicine (CN), Shaanxi University of Chinese Medicine (CN), Guangzhou Medical University (CN)
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Openalex Percentile: Top 68%
Phagocytosis and Immune Regulation
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LncRNA GAS6-AS2 regulates vascular smooth muscle cell senescence through the miR-138-5p/AKT1 axis and serves as a diagnostic and prognostic marker for atherosclerosis — Zhaochuan Luo, Wei Dong, et al. · Hereditas (2026) | TGRS Research Map | TGRS