Case Report: Durable disease stability in a patient with MET exon 14 skipping mutation and brain metastasis NSCLC following radiotherapy and immunotherapy

The combination of brain radiotherapy and camrelizumab demonstrated efficacy in a lung adenocarcinoma patient with BM and METex14. These findings suggest that immunotherapy may represent a potential treatment approach for high PD-L1 expression of METex14 NSCLC patients, warranting further investigation in larger cohorts.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-03
DOI
https://doi.org/10.3389/fimmu.2026.1719029
Citations
1
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
36.44

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article

Case Report: Durable disease stability in a patient with MET exon 14 skipping mutation and brain metastasis NSCLC following radiotherapy and immunotherapy

Dongfang Meng, Ji Ma, Yang Cui, Depeng Zhang et al.
1 citations
Frontiers in Immunology
Lung Cancer Treatments and Mutations
36.44
article

Case Report: Durable disease stability in a patient with MET exon 14 skipping mutation and brain metastasis NSCLC following radiotherapy and immunotherapy

Dongfang Meng, Ji Ma, Yang Cui, Depeng Zhang, Zhigang Wei, Xin Ye
article en
1 citations

Abstract

The combination of brain radiotherapy and camrelizumab demonstrated efficacy in a lung adenocarcinoma patient with BM and METex14. These findings suggest that immunotherapy may represent a potential treatment approach for high PD-L1 expression of METex14 NSCLC patients, warranting further investigation in larger cohorts.

Frontiers in ImmunologyVol. 17
Shandong University (CN), Shandong Tumor Hospital (CN), Boxing People's Hospital (CN), Shandong Provincial QianFoShan Hospital (CN), Shandong First Medical University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 1%
Lung Cancer Treatments and Mutations
36.44
DOIOpen Access PDFOpenAlex
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Case Report: Durable disease stability in a patient with MET exon 14 skipping mutation and brain metastasis NSCLC following radiotherapy and immunotherapy — Dongfang Meng, Ji Ma, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS