Calorie Restriction Leads to Degradation of Mutant Uromodulin and Ameliorates Inflammation and Fibrosis in UMOD-Related Kidney Disease
Calorie restriction enhanced autophagy and uromodulin degradation, counteracting the primary effect of UMOD mutations, and significantly ameliorated kidney disease onset and progression.
Authors
- Céline Schaeffer (ORCID: https://orcid.org/0000-0001-5883-3951)
- Barbara Canciani (ORCID: https://orcid.org/0000-0003-1942-1174)
- Benedetta Perrone (ORCID: https://orcid.org/0000-0002-9255-7492)
- Mariapia Giuditta Cratere
- Luca Rampoldi
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituto Clinico Sant'Ambrogio (IT)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1681/asn.0000001032
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00