Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis
Collectively, these results demonstrate that Gln confers robust protection against RIII by regulating the mTOR/Notch1 axis, alleviating Notch1 overactivation, and promoting GC differentiation. These findings provide valuable mechanistic insight and experimental support for Gln as a potential therapeutic agent to prevent or mitigate radiation-induced intestinal injury.
Authors
- Ye Jia
- Hongxia Li (ORCID: https://orcid.org/0000-0002-1440-1345)
- Heng Lu (ORCID: https://orcid.org/0009-0000-6562-4277)
- X. Ni
- Xinyu Liang (ORCID: https://orcid.org/0000-0003-0964-4294)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-5246-5497)
- Mengran Shi
- Qian Bai
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Second Military Medical University (CN)
- People 's Liberation Army 451 Hospital (CN)
- Air Force Engineering University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fonc.2026.1735401
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education of the People's Republic of China