Disrupted immune senescence in early pregnancy is associated with recurrent pregnancy loss
Pregnancy loss history is associated with both quantitative and qualitative alterations in immune senescence profiles, including organizational remodeling of peripheral immune senescence. Analysis of proinflammatory and regulatory T-cell subsets revealed additional associations, suggesting immune senescence may interact with adaptive immune polarization in early pregnancy. These findings highlight disrupted immune senescence as a potential component of immune maladaptation and identify senescent immune cells as candidate biomarkers for recurrent miscarriage.
Authors
- Dimitar Metodiev (ORCID: https://orcid.org/0000-0001-8056-3580)
- Georgi Stamenov (ORCID: https://orcid.org/0000-0002-4583-2711)
- Savina Petrova Hadjidekova (ORCID: https://orcid.org/0000-0002-4510-8512)
- Lachezar Jelezarsky
- Rumiana Ganeva (ORCID: https://orcid.org/0000-0002-1597-2414)
- Margarita Ruseva (ORCID: https://orcid.org/0000-0002-0361-3289)
- Dimitar Angelov Parvanov (ORCID: https://orcid.org/0000-0003-4992-002X)
- Jinahn Safir
- Maria Handzhiyska
Institutions
- Women's College Hospital (CA)
- Medical University of Sofia (BG)
- Women’s Health Care (US)
- B.C. Women's Hospital & Health Centre (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1705823
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission