Obesity Reprogrammes Adipose Extracellular Vesicles to Induce Muscle Atrophy via miR‐150‐5p‐Mediated Transcriptional Silencing
EVs from non-lean adipose tissue drive muscle atrophy and transcriptional changes in an age-dependent manner. These effects are partially mediated by miR-150-5p, highlighting a mechanistic role for EV cargo in adipose-muscle signalling. Targeting EV-derived miRNAs may offer a novel strategy to combat muscle loss in obesity and ageing.
Authors
- Thomas Nicholson (ORCID: https://orcid.org/0000-0001-5826-7312)
- Edward T. Davis (ORCID: https://orcid.org/0000-0003-2198-9068)
- Simon W. Jones (ORCID: https://orcid.org/0000-0001-6785-2310)
- Bethy Airstone
- Joshua M. J. Price
- Natalie Lachlan‐Jiraskova
- Kostas Tsintzas
- Caitlin M. Ditchfield
Institutions
- Oxford Brookes University (GB)
- Royal Orthopaedic Hospital (GB)
- Arthritis UK (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/jcsm.70204
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council
- Birmingham Biomedical Research Centre