Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA
We observed expected associations of plasma biomarkers with cognitive status and imaging biomarkers. GFAP, NfL, p-tau181, p-tau217, and p-tau231 are associated with cSVD in addition to AD-related pathology.
Authors
- Courtney L. Sutphen (ORCID: https://orcid.org/0000-0001-5005-2018)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Jordan E. Tanley (ORCID: https://orcid.org/0009-0006-0525-9662)
- Kevin D. Hiatt
- Przemysław Radosław Kac (ORCID: https://orcid.org/0000-0001-5083-0924)
- Bonnie C. Sachs (ORCID: https://orcid.org/0000-0002-9352-7033)
- Stephen R Rapp
- Kiran K. Solingapuram Sai
- K. Blennow
- T. Hughes
- Mohamad Habes
- Nicholas J. Ashton
- Henrik Zetterberg
- Susan R. Heckbert
- Suzanne Craft
- Christopher T. Whitlow
- Kathleen M. Hayden
- Thomas C. Register
- Thomas K. Karikari
- Michelle M. Mielke
- Samuel N. Lockhart
- Robert Koeppe
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- King's College London (GB)
- University of Washington (US)
- University of Michigan (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Michigan United (US)
- King's College School (GB)
- Pitié-Salpêtrière Hospital (FR)
- NIHR Maudsley Dementia Biomedical Research Unit (GB)
- University of Washington Applied Physics Laboratory (US)
- Banner Sun Health Research Institute (US)
- Perceptive Engineering (United Kingdom) (GB)
- University College London (GB)
- Wake Forest University (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71131
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences