Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA

We observed expected associations of plasma biomarkers with cognitive status and imaging biomarkers. GFAP, NfL, p-tau181, p-tau217, and p-tau231 are associated with cSVD in addition to AD-related pathology.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2026-02-01
DOI
https://doi.org/10.1002/alz.71131
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA

Courtney L. Sutphen, Fernando González‐Ortiz, Jordan E. Tanley, Kevin D. Hiatt et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA

Courtney L. Sutphen, Fernando González‐Ortiz, Jordan E. Tanley, Kevin D. Hiatt, Przemysław Radosław Kac, Bonnie C. Sachs, Stephen R Rapp, Kiran K. Solingapuram Sai, K. Blennow, T. Hughes, Mohamad Habes, Nicholas J. Ashton, Henrik Zetterberg, Susan R. Heckbert, Suzanne Craft, Christopher T. Whitlow, Kathleen M. Hayden, Thomas C. Register, Thomas K. Karikari, Michelle M. Mielke, Samuel N. Lockhart, Robert Koeppe
article en

Abstract

We observed expected associations of plasma biomarkers with cognitive status and imaging biomarkers. GFAP, NfL, p-tau181, p-tau217, and p-tau231 are associated with cSVD in addition to AD-related pathology.

Alzheimer s & DementiaVol. 22(2)
University of Science and Technology of China (CN), University of Wisconsin–Madison (US), The University of Texas at San Antonio Health Science Center (US), University of Pittsburgh (US), King's College London (GB), University of Washington (US), University of Michigan (US), Sahlgrenska University Hospital (SE), Sorbonne Université (FR), Michigan United (US), King's College School (GB), Pitié-Salpêtrière Hospital (FR), NIHR Maudsley Dementia Biomedical Research Unit (GB), University of Washington Applied Physics Laboratory (US), Banner Sun Health Research Institute (US), Perceptive Engineering (United Kingdom) (GB), University College London (GB), Wake Forest University (US), University of Gothenburg (SE)
National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences
Openalex Percentile: Top 70%
Dementia and Cognitive Impairment Research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.