Intermediate Conductance Calcium‐Activated Potassium Channel Activation in Stem Cell Antigen‐1 Positive Cells Contributed to Vascular Restenosis

This study clarifies the role of the IK<sub>Ca</sub>-TRPC1-Ca<sup>2+</sup> pathway in activating vascular Sca-1<sup>+</sup> cells and establishes the contribution of the IK<sub>Ca</sub> channel to vascular restenosis development. Understanding how IK<sub>Ca</sub> channels affect the function of vascular Sca-1<sup>+</sup> cells provides valuable insights into the complex mechanisms of vascular remodeling during vascular stenosis.

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Publication Details

Journal
Journal of the American Heart Association
Published
2026-02-03
DOI
https://doi.org/10.1161/jaha.125.045943
Primary Topic
Ion channel regulation and function
Type
article
Field-Weighted Citation Impact
0.00
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article

Intermediate Conductance Calcium‐Activated Potassium Channel Activation in Stem Cell Antigen‐1 Positive Cells Contributed to Vascular Restenosis

Pengyun Li, C F Li, Qingbo Xu, Mengying Zhu et al.
Journal of the American Heart Association
Ion channel regulation and function
article

Intermediate Conductance Calcium‐Activated Potassium Channel Activation in Stem Cell Antigen‐1 Positive Cells Contributed to Vascular Restenosis

Pengyun Li, C F Li, Qingbo Xu, Mengying Zhu, Jun Cheng, Tian Hai, Yan Yang, Yiting Liu, Xiangdong Yang, Xinyi Zeng, Min Zhang
article en

Abstract

This study clarifies the role of the IK<sub>Ca</sub>-TRPC1-Ca<sup>2+</sup> pathway in activating vascular Sca-1<sup>+</sup> cells and establishes the contribution of the IK<sub>Ca</sub> channel to vascular restenosis development. Understanding how IK<sub>Ca</sub> channels affect the function of vascular Sca-1<sup>+</sup> cells provides valuable insights into the complex mechanisms of vascular remodeling during vascular stenosis.

Journal of the American Heart AssociationVol. 15(4)
Southwest Medical University (CN), Affiliated Hospital of Southwest Medical University (CN)
Openalex Percentile: Top 69%
Ion channel regulation and function
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