Sex-specific nonlinear DNA methylation aging trajectories reveal biomarkers of cancer risk and inflammation
Our results uncover sex-specific, nonlinear aging programs that capture the dynamics of epigenetic change beyond linear models. These findings provide potential candidate biomarkers for early disease risk and advance understanding of how aging trajectories diverge between sexes.
Authors
- Nir Eynon (ORCID: https://orcid.org/0000-0003-4046-8276)
- Robin Grolaux (ORCID: https://orcid.org/0000-0001-5129-7308)
- Bernadette Jones-Freeman
- Macsue Jacques
- Steve Horvath
- Andrew Teschendorff
Institutions
- Australian Regenerative Medicine Institute (AU)
- Shanghai Institute of Nutrition and Health (CN)
- Monash University (AU)
Publication Details
- Journal
- Genome biology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s13059-026-03952-z
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health and Medical Research Council