Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort

Plasma ATN biomarkers demonstrate significant equity gaps and differential transportability across demographic subgroups. The 12-percentage-point sensitivity disparity and education-dependent effect modification highlight barriers to equitable implementation. Population-based validation with fairness metrics should be prerequisite for clinical deployment.

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Publication Details

Journal
medRxiv
Published
2026-02-03
DOI
https://doi.org/10.64898/2026.01.31.26344775
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort

Emmanuel Fle Chea
medRxiv
Dementia and Cognitive Impairment Research
article

Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort

Emmanuel Fle Chea
article en

Abstract

Plasma ATN biomarkers demonstrate significant equity gaps and differential transportability across demographic subgroups. The 12-percentage-point sensitivity disparity and education-dependent effect modification highlight barriers to equitable implementation. Population-based validation with fairness metrics should be prerequisite for clinical deployment.

medRxiv
University of Minnesota (US)
Gender equality
Openalex Percentile: Top 70%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort — Emmanuel Fle Chea · medRxiv (2026) | TGRS Research Map | TGRS