Combining network pharmacology and experimental validation to demonstrate that salidroside alleviates acute lung injury by inhibiting ferroptosis via the MAPK/GPX4 pathway
Integrated network pharmacology and experimental validation suggest that Sal pretreatment alleviates inflammatory response and oxidative stress, likely through regulation of the MAPK/GPX4 signaling pathway, thereby providing protection against lung tissue injury.
Authors
- Man Chen (ORCID: https://orcid.org/0009-0001-4052-2175)
- Meng Wang (ORCID: https://orcid.org/0000-0002-0650-2170)
- Min Zhao
- Wei Lin
- Wei Fang
Institutions
- Ministry of Culture (IN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1186/s12931-026-03529-1
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education
- Shandong First Medical University
- Shandong Academy of Medical Sciences