Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling

Together, these results demonstrate that maternal obesity, even in the absence of obesogenic diet, disrupts fetal bone marrow hematopoiesis by altered HSPC maturation, reprogramming lineage trajectories, and inducing inflammatory bias.

Authors

Brianna M. Doratt (ORCID: https://orcid.org/0000-0002-8107-724X)
Madison B. Blanton (ORCID: https://orcid.org/0000-0002-1515-1894)
Uriel Avila
Ilhem Messaoudi
Hami Hemati
Oleg Varlamov
Sheridan B. Wagner

Institutions

Oregon National Primate Research Center (US)
University of Kentucky (US)

Publication Details

Journal: bioRxiv (Cold Spring Harbor Laboratory)
Published: 2026-02-03
DOI: https://doi.org/10.64898/2026.01.29.702548
Primary Topic: Gestational Diabetes Research and Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling

Brianna M. Doratt, Madison B. Blanton, Uriel Avila, Ilhem Messaoudi et al.

Feb 3, 2026

bioRxiv (Cold Spring Harbor Laboratory)

Gestational Diabetes Research and Management

article

Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling

Brianna M. Doratt, Madison B. Blanton, Uriel Avila, Ilhem Messaoudi, Hami Hemati, Oleg Varlamov, Sheridan B. Wagner

February 3, 2026article en

Abstract

Together, these results demonstrate that maternal obesity, even in the absence of obesogenic diet, disrupts fetal bone marrow hematopoiesis by altered HSPC maturation, reprogramming lineage trajectories, and inducing inflammatory bias.

bioRxiv (Cold Spring Harbor Laboratory)

Oregon National Primate Research Center (US), University of Kentucky (US)

Good health and well-being

Openalex Percentile: Top 70%

Gestational Diabetes Research and Management

DOI Open Access PDF OpenAlex

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