Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF‐21), and insulin‐like growth factor binding protein 2 (IGFBP‐2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum
These findings suggest that IGFBP-2 and, to a lesser extent, FGF-21 may serve as early biomarkers of cognitive impairment, reflecting intricate links between peripheral dysmetabolism and AD.
Authors
- Andréanne Loiselle
- Caroline Dallaire‐Théroux (ORCID: https://orcid.org/0000-0003-1729-2209)
- Marine Tournissac (ORCID: https://orcid.org/0000-0002-1990-5075)
- Anne Gangloff (ORCID: https://orcid.org/0000-0002-6848-6559)
- Frédéric Picard (ORCID: https://orcid.org/0000-0003-4365-0743)
- Hélèna L. Denis (ORCID: https://orcid.org/0000-0003-1978-5058)
- Olivier Potvin (ORCID: https://orcid.org/0000-0001-9487-1920)
- Manon Leclerc (ORCID: https://orcid.org/0009-0009-5958-6599)
- Amélie Provencher
- Rosalie Juliette Cottez (ORCID: https://orcid.org/0009-0004-6233-9074)
- Frederic Calon
- Cyntia Tremblay
- S. Belleville
- Henrik Zetterberg
- Josue Valentin‐Escalera
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Lung Institute (US)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Hôpital de l'Enfant-Jésus (CA)
- Centre hospitalier de l'Université Laval (CA)
- National Hospital for Neurology and Neurosurgery (GB)
- Université Laval (CA)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71097
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- Réseau québécois de recherche sur le vieillissement
- Ministère de la Santé et des Services sociaux
- Consortium canadien en neurodégénérescence associée au vieillissement
- European Commission
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Courtois Foundation
- HORIZON EUROPE Framework Programme
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé