Prolonged severe acute respiratory syndrome coronavirus 2 infection and intrahost viral evolution in a severely immunocompromised patient with human immunodeficiency virus infection: A whole-genome sequencing study
Serial WGS in advanced HIV infection revealed a selective sweep with fixation of spike substitutions atypical of the infecting lineage, consistent with immune-driven adaptation during prolonged infection. These findings highlight that persistent infections under profound immunosuppression can generate antigenically and genetically distinct viruses, emphasizing the value of longitudinal sequencing and targeted monitoring/management strategies in severely immunocompromised hosts.
Authors
- Hiroyuki Gatanaga (ORCID: https://orcid.org/0000-0001-9191-9984)
- Katsuji Teruya (ORCID: https://orcid.org/0009-0006-6884-2134)
- K. Tsuchiya (ORCID: https://orcid.org/0000-0002-8233-6653)
- Kenshiro Kuroki
- Yoshiki Koizumi (ORCID: https://orcid.org/0000-0001-5124-1419)
- Takahiro Aoki (ORCID: https://orcid.org/0000-0002-9148-2871)
- Kazuhisa Yoshimura
- Takato Nakamoto
- Kenji Sadamasu
- Daisuke Mizushima
- Mami Nagashima
- Akira Kawashima
Institutions
- Kumamoto Health Science University (JP)
- National Center for Global Health and Medicine (JP)
- Tokyo Metropolitan Institute of Public Health (JP)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1016/j.ijid.2026.108453
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00