m6A demethylase–driven reprogramming of leukemia-associated macrophages predicts improved outcomes in acute myeloid leukemia
These results highlight m<sup>6</sup>A system's role in macrophage reprogramming and suggest that targeting m<sup>6</sup>A regulators in macrophages may serve as a potential basis for prognostic stratification and a promising therapeutic strategy in AML.
Authors
- Mingyue Zhang (ORCID: https://orcid.org/0000-0002-4719-1911)
- Yun An
- Tao Sun
- Zhiyu Shi
- Yuan Xia
- Qingjun Zhu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1739959
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shandong University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province