Retinol saturase promotes tubulointerstitial fibrosis in diabetic kidney disease by inhibiting ChREBP ubiquitination via Smurf2 suppression
These findings indicate that RetSat promotes TIF in DKD by disrupting the Smurf2-ChREBP ubiquitination axis, highlighting RetSat as a promising therapeutic target for DKD.
Authors
- Zhengqin Ye (ORCID: https://orcid.org/0000-0002-2743-3557)
- Lingling Pan (ORCID: https://orcid.org/0000-0002-4178-1910)
- Wenying Xu
- Ping Fang (ORCID: https://orcid.org/0000-0003-2327-7726)
- Yun Zhou (ORCID: https://orcid.org/0000-0002-5682-0169)
- Sijing Tang
- Y L Shi
- Ying Xue
- Jieli Huang
- Yang Wang
- Heming Huang
Institutions
- Tongji University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fendo.2026.1759785
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00