(PNM-56) Erectile dysfunction associated with air pollution: experimental study of the effects of fine particles (PM2.5) on penile function

Abstract Introduction Erectile dysfunction (ED) is frequently associated with endothelial dysfunction and oxidative stress, both of which are also caused by chronic exposure to air pollution, especially fine particulate matter (PM2.5). Although the cardiovascular effects of PM2.5 have been widely studied, its direct influence on penile function remains underexplored. This study aims to investigate this relationship in an animal model, expanding our understanding of environmental factors in male sexual health. Methodologies and Objectives This experimental study aims to analyze the influence of chronic exposure to PM2.5 on penile function in adult Wistar rats. The animals were divided into two groups: control and those exposed to fine particles by inhalation for 60 days. Physiological penile reactivity tests and histological analyses of the corpus cavernosum were performed, in addition to measuring nitric oxide (NO), malondialdehyde (MDA), and eNOS expression. Final Considerations This research reinforces the need to consider environmental factors as relevant components in the etiology of erectile dysfunction. Chronic exposure to fine particles can directly compromise erectile function through mechanisms of endothelial dysfunction and oxidative stress. This study contributes to a new understanding of environmental impacts on male sexual health and highlights the need to consider environmental factors as targets for prevention and clinical intervention. Financing No conflict.