Evaluating metagenomic sequencing as a stool-based diagnostic in children with presumptive TB in Uganda
Metagenomic sequencing of stool DNA did not increase sensitivity of TB detection, but identified novel targets for molecular testing that may support development of more sensitive tests.
Authors
- Gertrude Nannyonga
- Jascent Nakafeero
- Midori Kato‐Maeda (ORCID: https://orcid.org/0000-0003-0539-2472)
- Ashley R. Wolf (ORCID: https://orcid.org/0000-0001-8631-9837)
- Carolina Agudelo (ORCID: https://orcid.org/0000-0002-0624-3551)
- Moses Nsereko
- Kevin Nolan
- Rafaela Serra de Castro
- Eric Wobudeya
- Alfred Andama
- Devan Jaganath
- Sarrah Rose Mikhail Leung
- Adithya Cattamanchi
- Lucas Teran
Institutions
- University of California, San Francisco (US)
- University of California System (US)
- University of California, Irvine Medical Center (US)
- World Health Organization - Uganda (UG)
- Berkeley Public Health Division (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-03
- DOI
- https://doi.org/10.64898/2026.01.29.26345155
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Hellman Foundation
- National Institutes of Health