Complicated Catastrophic Calcium Gluconate Extravasation: Post‐Surgical Graft Calcinosis Cutis

Extravasation is a rare but serious complication of intravenous injections, particularly with irritant or vesicant drugs, which can lead to significant tissue damage. In this case report, we describe a 14-year-old boy who developed calcinosis cutis due to extravasation of calcium gluconate, resulting in extensive tissue necrosis. Although surgical debridement and grafting were performed, the patient subsequently experienced iatrogenic post-surgical graft calcinosis cutis, leading to severe hand disability. This case underscores the importance of prompt recognition and management of extravasation to prevent long-term complications.

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Publication Details

Journal
Clinical Case Reports
Published
2026-02-01
DOI
https://doi.org/10.1002/ccr3.71986
Primary Topic
Chemotherapy-related skin toxicity
Type
article
Field-Weighted Citation Impact
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article

Complicated Catastrophic Calcium Gluconate Extravasation: Post‐Surgical Graft Calcinosis Cutis

Nasim Kakavand, fereshte rastegarnasab, Bahareh Abtahi‐Naeini
Clinical Case Reports
Chemotherapy-related skin toxicity
article

Complicated Catastrophic Calcium Gluconate Extravasation: Post‐Surgical Graft Calcinosis Cutis

Nasim Kakavand, fereshte rastegarnasab, Bahareh Abtahi‐Naeini
article en

Abstract

Extravasation is a rare but serious complication of intravenous injections, particularly with irritant or vesicant drugs, which can lead to significant tissue damage. In this case report, we describe a 14-year-old boy who developed calcinosis cutis due to extravasation of calcium gluconate, resulting in extensive tissue necrosis. Although surgical debridement and grafting were performed, the patient subsequently experienced iatrogenic post-surgical graft calcinosis cutis, leading to severe hand disability. This case underscores the importance of prompt recognition and management of extravasation to prevent long-term complications.

Clinical Case ReportsVol. 14(2)
Isfahan University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 69%
Chemotherapy-related skin toxicity
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