What is the best approach to blood transfusion in sickle cell disease? A scientometric analysis and literature review
We conclude that the future of transfusion safety in SCD does not lie in a binary choice but rather in a synergistic and stratified integration of both strategies. Implementing protocols that target genotyping for high-risk patients, while simultaneously optimising the use of extended phenotyping, represents the most promising pathway to balance safety, cost and accessibility-ultimately ensuring the best possible transfusion therapy for this vulnerable population.
Authors
- Sarah Cristina Sato Vaz Tanaka (ORCID: https://orcid.org/0000-0003-4466-6093)
- Hélio Moraes de Souza
- Anna Cecília Dias Maciel Carneiro (ORCID: https://orcid.org/0000-0003-4865-1286)
- Christiane Ruffato Carminati (ORCID: https://orcid.org/0000-0003-2334-4570)
- Fernanda Bernadelli De Vito (ORCID: https://orcid.org/0000-0002-7407-4972)
- Lucas Fernandes Ananias
- Saulo Fernando Moreira da Silva
Institutions
- Universidade Federal do Triângulo Mineiro (BR)
Publication Details
- Journal
- Transfusion Medicine
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1111/tme.70064
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00