Targeting lipophagy and nuclear receptors in metabolic-associated fatty liver disease: insights from traditional Chinese medicine
TCM (including herbal compound preparations, extracts, and active metabolites) exerts therapeutic effects on MAFLD by inducing lipophagy through diverse pharmacological mechanisms and NR-associated signaling pathways. These agents emerge as promising focal points for MAFLD basic research and potential candidates for MAFLD drug development, offering reduced side effects and enhanced therapeutic efficacy.
Authors
- Xiang He (ORCID: https://orcid.org/0000-0002-7690-0289)
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Ziming Zhao (ORCID: https://orcid.org/0000-0003-1455-4330)
- Lili Yu
- N.Y. Huang
- Ting Yue
- Yi Zheng
Institutions
- Macau University of Science and Technology (MO)
- Zhejiang Chinese Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fphar.2025.1744069
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00