COMPARING HIGH-GRADE NON-RHABDOMYOSARCOMA SOFT-TISSUE SARCOMA IN ADULT AND PAEDIATRIC POPULATIONS

Soft tissue sarcoma (STS) is rare in pediatric patients with treatment and outcomes data lacking compared to adults. The purpose of this study is to compare our institution's treatment and oncologic outcomes of high-grade STS in adults and children Four-hundred-and-fourteen (383 adult:31 pediatric) patients with high-grade non-rhabdomyosarcoma extremity STS were reviewed. Mean age at diagnosis was 63±15 and 11±5 years in adults and children, respectively. Mean follow-up was 5±4 years. Mean tumor size was similar in adults and children (9±6 vs. 8±7 cm, p = 0.6) as were rates of metastatic disease on presentation (6% vs. 6%, p = 0.9). Pre-operative radiation therapy was employed more frequently in adults (83% vs. 45%, p Treatment of high-grade STS was treated differently in pediatric and adult patients with pre-operative radiation more utilized in adults and post-operative chemotherapy more utilized in children. LRFS and MDFS, however, were similar between groups with greater OS of the pediatric cohort.