Hepatic GPR75 exacerbates MASH through GNAI2-dependent signaling
This study demonstrates that GPR75 serves as a novel regulator of MASLD/MASH by modulating hepatic fatty acid metabolism. These findings suggest that GPR75 suppression may represent a potential therapeutic strategy for MASLD/MASH treatment.
Authors
- R Zhang
- Na Yang (ORCID: https://orcid.org/0000-0002-5033-0978)
- Hongye Fan
- Yuan Xie (ORCID: https://orcid.org/0000-0002-2991-6763)
- Xule Yang (ORCID: https://orcid.org/0009-0004-4560-8682)
- Jiye Aa
Institutions
- China Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Natural Medicine
Publication Details
- Journal
- Hepatology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1097/hep.0000000000001706
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00