NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model
Our findings suggest that NRF2 loss induces a hippocampal state marked by impaired antioxidant defenses, astrocytic remodeling, and disrupted tau isoform balance. This environment, while metabolically altered, paradoxically hinders tau propagation, highlighting NRF2 as a key regulator of both redox and cellular maturity programs essential for tau spread and as a potential therapeutic target in tauopathies.
Authors
- Antònia Vinyals (ORCID: https://orcid.org/0000-0003-3925-0050)
- Pol Andrés‐Benito (ORCID: https://orcid.org/0000-0003-3000-0338)
- Xoel Mato-Blanco (ORCID: https://orcid.org/0000-0003-2155-9922)
- Sergio Roca-Pereira
- José Antonio del Rio
- Marta Vela-Martínez
- Farida Dakterzada
- Enrique Santamaría
- Isidro Ferrer
- Joaquín Fernández-Irigoyen
- Yaiza López-Sampere
- Mónica Povedano
- Gabriel Santpere
- Leila Romero
- Pol Mengod Soler
Institutions
- Barcelona Biomedical Research Park (ES)
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Navarrabiomed (ES)
- Instituto de Investigación Biomédica de Lleida (ES)
- Institute for Bioengineering of Catalonia (ES)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1016/j.redox.2026.104068
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00