Vascular remodelling and fibrotic changes in the joint capsule during periprosthetic knee infections
PJI is associated with profound vascular remodelling and fibrotic transformation of the joint capsule, marked by aberrant angiogenesis, disrupted vessel architecture, and distinct gene expression profiles. These alterations may impair tissue perfusion, compromise immune surveillance, and hinder antibiotic delivery, thereby contributing to recurrent infection. Targeting soft-tissue vascularization and fibrosis may represent a novel therapeutic strategy to reduce PJI recurrence and enhance surgical outcomes.
Authors
- Stefanie Donner (ORCID: https://orcid.org/0000-0001-8270-0462)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Stephanie Kirschbaum (ORCID: https://orcid.org/0000-0001-8263-4354)
- Clemens Gwinner (ORCID: https://orcid.org/0000-0001-7489-245X)
- Julia Mehl (ORCID: https://orcid.org/0000-0002-8279-7142)
- Carsten Perka (ORCID: https://orcid.org/0000-0002-0993-581X)
- Denise Jahn (ORCID: https://orcid.org/0000-0001-8912-5851)
- Renqiu Qiao
- Ellen Sistemich
- Mario Thiele
- Bo Qi
- Arne Kienzle
- Wei Fan
Institutions
- Humboldt-Universität zu Berlin (DE)
- People's Liberation Army No. 150 Hospital (CN)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1302/2046-3758.152.bjr-2025-0203.r1
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00