Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis

Cognitive outcomes in LGI1 autoimmune encephalitis improve after immunotherapy, yet executive dysfunction frequently persists as a long-term deficit. Older age independently predicts poorer outcomes, suggesting that age-related vulnerability may limit recovery.

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Publication Details

Journal
Journal of the Neurological Sciences
Published
2026-02-03
DOI
https://doi.org/10.1016/j.jns.2026.125789
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
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article

Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis

Dror Shir, Yifat Alcalay, Avi Gadoth, Yael Paran et al.
Journal of the Neurological Sciences
Autoimmune Neurological Disorders and Treatments
article

Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis

Dror Shir, Yifat Alcalay, Avi Gadoth, Yael Paran, Orna Aizenstein
article en

Abstract

Cognitive outcomes in LGI1 autoimmune encephalitis improve after immunotherapy, yet executive dysfunction frequently persists as a long-term deficit. Older age independently predicts poorer outcomes, suggesting that age-related vulnerability may limit recovery.

Journal of the Neurological SciencesVol. 482
Tel Aviv University (IL), Tel Aviv Sourasky Medical Center (IL)
No poverty
Openalex Percentile: Top 70%
Autoimmune Neurological Disorders and Treatments
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Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis — Dror Shir, Yifat Alcalay, et al. · Journal of the Neurological Sciences (2026) | TGRS Research Map | TGRS