Overexpression of Soluble Fibrinogen-like Protein 2 in MSCs Ameliorates Renal Ischemia-Reperfusion Injury in Mice by Modulating Neutrophils
Genetically modified sFgl2-MSCs alleviate renal I/R injury. This protective effect is associated with engagement of neutrophil CD32b receptors, activation of the TGFβ-Smad2/3 pathway, promotion of a protective N2-like neutrophil phenotype, and suppression of N1-like and NET-related markers.
Authors
- P. Zhang
- Wenhao Xiong
- Guo-Shan Chen
- Yi-Ting Wang
- Feng Qi
- Yong-Chao Zhang
- Dan-Zhou Li
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Balkan Medical Journal
- Published
- 2026-02-03
- DOI
- https://doi.org/10.4274/balkanmedj.galenos.2026.2025-12-101
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00