ACADL and ADH1B signify ketone body metabolic reprogramming in osteoarthritic synovium: insights from bioinformatics and animal model studies
<i>ACADL</i> and <i>ADH1B</i> link KBM abnormalities to immune dysregulation in the OA synovium. The nomogram enables the precise early diagnosis of OA, and progesterone and fomepizole are promising targeted therapies. These findings deepen the current understanding of OA pathogenesis and support the advancement of personalized treatments for clinical translation.
Authors
- Yuan Yu (ORCID: https://orcid.org/0000-0001-5453-2377)
- Jiawei Guo (ORCID: https://orcid.org/0009-0006-7823-2508)
- Siyao Yang
- Xun Yang
- Bingshu Chen
- Meng He
- Jinteng Liu
- Kuokuo Li
Institutions
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- University of Jinan (CN)
- Jinan University (LB)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fmed.2026.1700784
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00