Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways
Reduced fetal growth may be driven by lipodystrophy-related insulin resistance and IFG-related insulin deficiency pathways. Targeting pregnant women with high type 2 diabetes PRS/pPRS and prescribing interventions to reduce their post-load hyperglycaemia and BMI may help reduce offspring risk of LGA.
Authors
- MAI SHI
- Alice E. Hughes (ORCID: https://orcid.org/0000-0003-1352-4447)
- Professor Wing Hung Tam
- GECHANG YU
- Chuiguo Huang
- Cadmon K. P. Lim
- Ronald C. W. Ma
- Claudia H. T. Tam
- Yuzhi Deng
- Michael N. Weedon
- Richard A. Oram
- Chi Chiu Wang
- Juliana C. N. Chan
- Rachel M. Freathy
Institutions
- Northwestern University (US)
- Chinese University of Hong Kong (HK)
- University of Exeter (GB)
- Shatin Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Diabetologia
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1007/s00125-026-06669-7
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Impact Fund
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- Chinese University of Hong Kong
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development